Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multicentre randomised clinical trial.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F22%3AA2302IC2" target="_blank" >RIV/61988987:17110/22:A2302IC2 - isvavai.cz</a>

Result on the web

<a href="https://www.dhmjournal.com/index.php/journals?id=304" target="_blank" >https://www.dhmjournal.com/index.php/journals?id=304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.28920/dhm52.3.164-174" target="_blank" >10.28920/dhm52.3.164-174</a>

Result language

angličtina

Original language name

Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multicentre randomised clinical trial.

Original language description

Introduction: Hyperbaric oxygen treatment (HBOT) is sometimes used in the management of open fractures and severe soft tissue crush injury, aiming to reduce complications and improve outcomes. Methods: Patients with open tibial fractures were randomly assigned within 48 hours of injury to receive standard trauma care or standard care plus 12 sessions of HBOT. The primary outcome was the incidence of necrosis or infection or both occurring within 14 days of injury. Results: One-hundred and twenty patients were enrolled. Intention to treat primary outcome occurred in 25/58 HBOT assigned patients and 34/59 controls (43% vs 58%, odds ratio (OR) 0.55, 95% confidence interval (CI) 0.25 to 1.18, P = 0.12). Tissue necrosis occurred in 29% of HBOT patients and 53% of controls (OR 0.35, 95% CI 0.16 to 0.78, P = 0.01). There were fewer late complications in patients receiving HBOT (6/53 vs 18/52, OR 0.22, 95% CI 0.08 to 0.64, P = 0.007) including delayed fracture union (5/53 vs 13/52, OR 0.31, 95% CI 0.10 to 0.95, P = 0.04). Quality of life measures at one and two years were superior in HBOT patients. The mean score difference in short form 36 was 2.90, 95% CI 1.03 to 4.77, P = 0.002, in the short musculoskeletal function assessment (SMFA) was 2.54, 95% CI 0.62 to 4.46, P = 0.01; and in SMFA daily activities was 19.51, 95% CI 0.06 to 21.08, P = 0.05. Conclusions: In severe lower limb trauma, early HBOT reduces tissue necrosis and the likelihood of long-term complications, and improves functional outcomes. Future research should focus on optimal dosage and whether HBOT has benefits for other injury types.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30230 - Other clinical medicine subjects

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diving and Hyperbaric Medicine

ISSN

2209-1491

e-ISSN

—

Volume of the periodical

—

Issue of the periodical within the volume

3

Country of publishing house

AU - AUSTRALIA

Number of pages

11

Pages from-to

164-174

UT code for WoS article

000871578600002

EID of the result in the Scopus database

—