Predicting Acute Kidney Injury in Trauma Patients: Biomarkers as Early Indicators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F23%3AA2402NNX" target="_blank" >RIV/61988987:17110/23:A2402NNX - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795410/pdf/medscimonit-30-e942271.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795410/pdf/medscimonit-30-e942271.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.942271" target="_blank" >10.12659/MSM.942271</a>

Result language

angličtina

Original language name

Predicting Acute Kidney Injury in Trauma Patients: Biomarkers as Early Indicators

Original language description

Background: Acute kidney injury (AKI) is a common cause of organ failure in patients after major trauma and is associated with increased morbidity and mortality. Early identification of patients at risk enables the implementation of a bundle of supportive care, which reduces the incidence of AKI. The primary objective of our study was to investigate whether the levels of biomarkers on admission predicted the onset of early AKI in patients with serious injuries. Material/Methods: This prospective observational study included 98 adult patients of both sexes with a serious injury (injury severity score >16). At admission, blood samples were taken, and creatinine, neutrophil gelatinase-associated lipocalin (NGAL), high mobility group box 1 (HMGB-1), and markers of rhabdomyolysis (creatine kinase, myoglobin) were evaluated. The patients were provided with standard resuscitation care, and the occurrence of AKI was monitored during the first 7 days after admission to the Intensive Care Unit, according to the Kidney Disease Improving Global Outcomes diagnostic criteria. Results: AKI occurred in 25 (25.5%) patients, in whom the admission levels of HMGB-1, NGAL, creatinine, and myoglobin were significantly higher than in non-AKI patients (48.3±98.4 vs 113.0±209.4 µg/L, P=0.006; 150.2±349.9 vs 181.4±152.2 µg/L, P=0.004; 83.1±20.8 vs 118.8±32.2 µmol/L, P<0.005; 2734.4±2214.5 vs 4182.3±2477.1 µg/L, P=0.008, respectively). Creatine kinase was 14.5±9.2 µkat/L in non-AKI patients and 13.7±7.9 µkat/L in AKI patients (P=0.916). Conclusions: Admission levels of HMGB-1, NGAL, creatinine, and myoglobin predicted the risk of AKI in severely injured patients. © Med Sci Monit,

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30221 - Critical care medicine and Emergency medicine

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Science Monitor

ISSN

1234-1010

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

2023

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

001182292100001

EID of the result in the Scopus database

2-s2.0-85178110133