Does the healthy vaccinee bias rule them all? Association of COVID-19 vaccination status and all-cause mortality from an analysis of data from 2.2 million individual health records
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F24%3AA2503AKB" target="_blank" >RIV/61988987:17110/24:A2503AKB - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73627551
Result on the web
<a href="https://linkinghub.elsevier.com/retrieve/pii/S1201971224000468" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S1201971224000468</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijid.2024.02.019" target="_blank" >10.1016/j.ijid.2024.02.019</a>
Alternative languages
Result language
angličtina
Original language name
Does the healthy vaccinee bias rule them all? Association of COVID-19 vaccination status and all-cause mortality from an analysis of data from 2.2 million individual health records
Original language description
Objectives: We investigated the validity of claims of the healthy vaccinee effect (HVE) in COVID-vaccine studies by analyzing associations between all -cause mortality (ACM) and COVID-19 vaccination status. Methods: Approximately 2.2 million individual records from two Czech health insurance companies were retrospectively analyzed. Each age group was stratified according to the vaccination status (unvaccinated vs. individuals less than 4 weeks vs. more than 4 weeks from Doses 1, 2, 3, and 4 or more doses of vaccine). ACMs in these groups were computed and compared. Results: Consistently over datasets and age categories, ACM was substantially lower in the vaccinated than unvaccinated groups regardless of the presence or absence of a wave of COVID-19 deaths. Moreover, the ACMs in groups more than 4 weeks from Doses 1, 2, or 3 were consistently several times higher than in those less than 4 weeks from the respective dose. HVE appears to be the only plausible explanation for this, which is further corroborated by a created mathematical model. Conclusions: In view of the presence of HVE, the baseline difference in the frailty of vaccinated and unvaccinated populations in periods without COVID-19 must be taken into account when estimating COVID19 vaccine effectiveness from observational data. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INT J INFECT DIS
ISSN
1201-9712
e-ISSN
1878-3511
Volume of the periodical
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Issue of the periodical within the volume
May 2024
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
001224649700001
EID of the result in the Scopus database
2-s2.0-85188557163