Exploring the relationship between air pollution and telomere length: Baseline findings from a comprehensive ambispective cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603CKJ" target="_blank" >RIV/61988987:17110/25:A2603CKJ - isvavai.cz</a>
Result on the web
<a href="https://linkinghub.elsevier.com/retrieve/pii/S1438463925000598" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S1438463925000598</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijheh.2025.114577" target="_blank" >10.1016/j.ijheh.2025.114577</a>
Alternative languages
Result language
angličtina
Original language name
Exploring the relationship between air pollution and telomere length: Baseline findings from a comprehensive ambispective cohort study
Original language description
Background: Telomere length is a biomarker of cellular aging, influenced by various environmental and lifestyle factors. Air pollution is a known environmental stressor that may impact telomere dynamics. This study aimed to investigate the effect of age, lifetime exposure to air pollution, inflammatory parameters and selected lifestyle factors on telomere length. Methods: The study included 356 participants aged 35-65 living in two regions with varying pollution. Telomere length was measured using qPCR. Individual lifetime exposures to PM10, PM2.5, NO2, benzo(a)pyrene and benzene were calculated based on historical air quality data. Statistical analysis of age, pollution exposure, inflammatory parameters, and lifestyle factors on telomere length was performed using logistic regression and generalized linear models, with odds ratios calculated. Results: Unexpectedly, higher air pollutants lifetime exposures were associated with longer telomeres, particularly for PM10 51-55 mu g/m(3) (OR = 5.67, p < 0.001), PM2.5 42-45 mu g/m(3) (OR = 6.56, p < 0.001), B(a)P 6.9-8.3 ng/m(3) (OR = 5.25, p = 0.002), NO2 26-27 mu g/m(3) (OR = 5.22, p = 0.001) and benzene 2.45-2.75 mu g/m(3) (OR = 6.13, p < 0.001). Age significantly affected telomere length, with older individuals having shorter telomeres. Socioeconomic factors such as college education were positively associated with longer telomeres, while lifestyle factors did not show significant associations. IL-8 was identified as a significant inflammatory marker negatively associated with very long telomeres. Conclusion: These baseline findings bring new perspective to the relationship between air pollution and telomere length. Contrary to traditional views, the results suggest potential adaptive responses, highlighting the need for further longitudinal research to explore telomere dynamics over time in conjunction with other factors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Hygiene and Environmental Health
ISSN
1438-4639
e-ISSN
1618-131X
Volume of the periodical
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Issue of the periodical within the volume
June 2025
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
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UT code for WoS article
001470540500001
EID of the result in the Scopus database
2-s2.0-105002311889