Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603DNX" target="_blank" >RIV/61988987:17110/25:A2603DNX - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10497691

Result on the web

<a href="https://www.nature.com/articles/s41598-025-91830-2" target="_blank" >https://www.nature.com/articles/s41598-025-91830-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-91830-2" target="_blank" >10.1038/s41598-025-91830-2</a>

Result language

angličtina

Original language name

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma

Original language description

The aim of this study was to evaluate the effects of pleuran (beta-glucan isolated from Pleurotus ostreatus) on asthma control and respiratory morbidity in children on conventional GINA-based asthma treatment who had partially controlled perennial asthma. A double-blind, placebo-controlled multicentre clinical trial with a 2-arm, parallel design was conducted across three countries; 230 children aged 7 to 17 years were randomised (1:1) into an active group (receiving a pleuran/vitamin C combination) or a placebo group (receiving vitamin C only). This study consisted of 24 weeks of treatment (2 capsules a day) and then 24 weeks of follow-up. The primary endpoints included the effects of active treatment versus placebo on asthma control and respiratory tract infections (RTIs). Secondary endpoints included changes in the following measures: number of asthma exacerbations, with or without respiratory infection; quality of life of both asthmatic children and their caregivers; spirometric indices; fractional exhaled nitric oxide (FeNO) levels; safety after 24 weeks of treatment and also after the full 48-week study period. Overall, 206 children completed this study; 113 of these children were in the active group and received a pleuran/vitamin C combination for 24 weeks. After the 24-week treatment period, children below 12 years of age who were in the active group achieved significant improvements in asthma control compared to those in the placebo group (21.8 +/- 3.5 vs. 20.3 +/- 4.0; P = 0.02); while children at least 12 years old who were in the active group reported lower numbers of RTIs (0.7 +/- 1.0 vs. 1.9 +/- 1.7; P = 0.002) compared to children of this age in the placebo group. In addition, children below 12 years of age in the active group showed a significant decrease in asthma exacerbations compared to those in the placebo group (2.5 +/- 1.6 vs. 3.3 +/- 1.9; P = 0.05). At the end of the 48-week trial, a statistically significant improvement in asthma control was observed in 84.7% of children who received pleuran/vitamin C treatment compared to 67.0% of children who received vitamin C only (P = 0.01). The pleuran/vitamin C combined treatment was safe and well-tolerated, and no related serious adverse events were reported. This study highlights the favourable safety profile of pleuran/vitamin C supplementation and demonstrates positive effects of this treatment on asthma control and RTI incidence in children with allergic perennial asthma that was partially controlled by conventional therapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30500 - Other medical sciences

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

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Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

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UT code for WoS article

001435277400020

EID of the result in the Scopus database

2-s2.0-85219642244