Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F12%3AA130176A" target="_blank" >RIV/61988987:17310/12:A130176A - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?
Original language description
Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined thegenome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encodedby an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunit
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GAP305%2F10%2F0205" target="_blank" >GAP305/10/0205: The Ras superfamily of GTPases and the evolution of the eukaryotic cell</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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