Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F16%3AA1701JCI" target="_blank" >RIV/61988987:17310/16:A1701JCI - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera
Original language description
Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract?s ability to inhibit mutagenicity induced by tert-butyl ydroperoxide (t-BHP) and hydrogen peroxide (H2O2)was determined with Ames test using Salmonella typhimurium His TA102 strain. Inhibition values of 44.2 % and 67.0% were d etected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scis-sion induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/LO1208" target="_blank" >LO1208: Theoretical aspects of Energetic treatment of Waste and Environment Protection against negative impacts</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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