Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophilal
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F17%3AA1801OCM" target="_blank" >RIV/61988987:17310/17:A1801OCM - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/17:00485299 RIV/60076658:12310/17:43895459 RIV/00216208:11310/17:10360335
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0174165" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0174165</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0174165" target="_blank" >10.1371/journal.pone.0174165</a>
Alternative languages
Result language
angličtina
Original language name
Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophilal
Original language description
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23 degrees C) and elevated (34 degrees C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
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UT code for WoS article
000399094700063
EID of the result in the Scopus database
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