Influenza virus infection causes global RNAPII termination defects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901X1D" target="_blank" >RIV/61988987:17310/18:A1901X1D - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/s41594-018-0124-7" target="_blank" >http://dx.doi.org/10.1038/s41594-018-0124-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41594-018-0124-7" target="_blank" >10.1038/s41594-018-0124-7</a>
Alternative languages
Result language
angličtina
Original language name
Influenza virus infection causes global RNAPII termination defects
Original language description
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global transcriptional defects at the 3' ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions. Deregulated RNAPII leads to expression of aberrant RNAs (3' extensions and host-gene fusions) that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral response and virulence. This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. Our data identify a strategy used by IAV to suppress host gene expression and indicate that polymorphisms in IDRs of viral proteins can affect the outcome of an infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NATURE STRUCTURAL & MOLECULAR BIOLOGY
ISSN
1545-9993
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
885-893
UT code for WoS article
000443839200019
EID of the result in the Scopus database
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