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Influenza virus infection causes global RNAPII termination defects

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901X1D" target="_blank" >RIV/61988987:17310/18:A1901X1D - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1038/s41594-018-0124-7" target="_blank" >http://dx.doi.org/10.1038/s41594-018-0124-7</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41594-018-0124-7" target="_blank" >10.1038/s41594-018-0124-7</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Influenza virus infection causes global RNAPII termination defects

  • Original language description

    Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infection induces global transcriptional defects at the 3' ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions. Deregulated RNAPII leads to expression of aberrant RNAs (3' extensions and host-gene fusions) that ultimately cause global transcriptional downregulation of physiological transcripts, an effect influencing antiviral response and virulence. This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. Our data identify a strategy used by IAV to suppress host gene expression and indicate that polymorphisms in IDRs of viral proteins can affect the outcome of an infection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    NATURE STRUCTURAL & MOLECULAR BIOLOGY

  • ISSN

    1545-9993

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    885-893

  • UT code for WoS article

    000443839200019

  • EID of the result in the Scopus database