Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21027WN" target="_blank" >RIV/61988987:17310/20:A21027WN - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/20:00523977 RIV/62156489:43110/20:43916735 RIV/00216305:26310/20:PU133360
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0888754319305269" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0888754319305269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2019.11.002" target="_blank" >10.1016/j.ygeno.2019.11.002</a>

Result language
angličtina
Original language name
Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae
Original language description
The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/GA18-15548S" target="_blank" >GA18-15548S: Comparative study of DNA interacting properties of the tumor suppressor p53 protein isoforms</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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