Expansion and transformation of the minor spliceosomal system in the slime mold Physarum polycephalum

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202AFB" target="_blank" >RIV/61988987:17310/21:A2202AFB - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0960982221005972?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0960982221005972?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cub.2021.04.050" target="_blank" >10.1016/j.cub.2021.04.050</a>

Result language
angličtina
Original language name
Expansion and transformation of the minor spliceosomal system in the slime mold Physarum polycephalum
Original language description
Spliceosomal introns interrupt nuclear genes and are removed from RNA transcripts ('spliced'') by machinery called spliceosomes. Although the vast majority of spliceosomal introns are removed by the so-called major (or 'U2'') spliceosome, diverse eukaryotes also contain a rare second form, the minor ('U12'') spliceosome, and associated ('U12-type'') introns.(1-3) In all characterized species, U12-type introns are distinguished by several features, including being rare in the genome (similar to 0.5% of all introns),(4-6) containing extended evolutionarily conserved splicing motifs,(4,5,7,8) being generally ancient,(9,10) and being inefficiently spliced.(11-13) Here, we report a remarkable exception in the slime mold Physarum polycephalum. The P. polycephalum genome contains >20,000 U12-type introns-25 times more than any other species-enriched in a diversity of non-canonical splice boundaries as well as transformed splicing signals that appear to have co-evolved with the spliceosome due to massive gain of efficiently spliced U12-type introns. These results reveal an unappreciated dynamism of minor spliceosomal introns and spliceosomal introns in general.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)