Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202CAM" target="_blank" >RIV/61988987:17310/21:A2202CAM - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010041" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0010041" target="_blank" >10.1371/journal.pntd.0010041</a>
Alternative languages
Result language
angličtina
Original language name
Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana
Original language description
Author summaryParasites of the genus Leishmania cause leishmaniasis, a neglected tropical disease. Telomeric and sub-telomeric regions of these flagellates are often associated with virulence. That is why studying telomere maintenance is important. Here we demonstrate that deletion of one of the proteins, implicated in telomere maintenance, resulted in elongated telomeres. This is unexpected, because deletion of the same gene in another model organism, Trypanosoma brucei, has an opposite effect. Previous comparative genomic studies suggested that the protein under study might be also involved in genome stability. Nevertheless, we did not detect any trace of genomic instability in L. mexicana after 100 passages. We concluded that Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centre for research of pathogenicity and virulence of parasites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLOS NEGLECT TROP D
ISSN
1935-2735
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
—
UT code for WoS article
000738780800002
EID of the result in the Scopus database
—