Trypanosoma cruzi strain and starvation-driven mitochondrial RNA editing and transcriptome variability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F22%3AA2302GR4" target="_blank" >RIV/61988987:17310/22:A2302GR4 - isvavai.cz</a>
Result on the web
<a href="https://rnajournal.cshlp.org/content/28/7/993" target="_blank" >https://rnajournal.cshlp.org/content/28/7/993</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.079088.121" target="_blank" >10.1261/rna.079088.121</a>
Alternative languages
Result language
angličtina
Original language name
Trypanosoma cruzi strain and starvation-driven mitochondrial RNA editing and transcriptome variability
Original language description
Trypanosoma cruzi is a unicellular protistan parasitic species that is comprised of strains and isolates exhibiting high levels of genetic and metabolic variability. In the insect vector, it is known to be highly responsive to starvation, a signal for progression to a life stage in which it can infect mammalian cells. Most mRNAs encoded in its mitochondrion require the targeted insertion and deletion of uridines to become translatable transcripts. This study defined differences in uridine-insertion/deletion RNA editing among three strains and established the mechanism whereby abundances of edited (and, thus, translatable) mitochondrial gene products increase during starvation. Our approach utilized our custom T-Aligner toolkit to describe transcriptome-wide editing events and reconstruct editing products from high-throughput sequencing data.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA
ISSN
1355-8382
e-ISSN
1469-9001
Volume of the periodical
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Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
993-1012
UT code for WoS article
000812825700006
EID of the result in the Scopus database
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