Effects of a four-week very low-carbohydrate high-fat diet on biomarkers of inflammation: Non-randomised parallel-group study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17450%2F20%3AA21024XZ" target="_blank" >RIV/61988987:17450/20:A21024XZ - isvavai.cz</a>
Result on the web
<a href="https://journals.sagepub.com/doi/abs/10.1177/0260106020903206" target="_blank" >https://journals.sagepub.com/doi/abs/10.1177/0260106020903206</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0260106020903206" target="_blank" >10.1177/0260106020903206</a>
Alternative languages
Result language
angličtina
Original language name
Effects of a four-week very low-carbohydrate high-fat diet on biomarkers of inflammation: Non-randomised parallel-group study
Original language description
Background: It is commonly assumed that increased dietary fat and/or caloric excess induces chronic inflammatory processes, since the association between obesity and chronic adipose tissue with systemic inflammation has been shown previously. As far as we know, the reported health benefits of a VLCHF or ketogenic diet have not adequately involved an evaluation of biomarkers of inflammation. Aim: This study investigated the effects of a four-week very low-carbohydrate high-fat (VLCHF) diet in healthy young individuals on biomarkers of inflammation. Methods: Eighteen moderately trained males (age 23.8 ± 2.1 years) were assigned to two groups. One group switched to a non-standardised VLCHF diet for four weeks, while the second group remained consuming their normal habitual diet (HD). Biomarkers of inflammation (adiponectin, leptin, resistin and interleukin-6) and substrate metabolism (fasting glucose and triacylglyceride concentrations) were analysed from blood at baseline and after four weeks. Results: There was moderate evidence for substantial changes in leptin serum concentrations in the VLCHF group, with small to large decreases compared to the HD group after four weeks (effect size = 0.78, 95% CI 0.42, 0.93, p = 0.008; Bayes Factor10 = 5.70). No substantial between-group change differences over time were found across any other biomarkers. Conclusions: A four-week period of consuming a VLCHF diet in healthy young men was not associated with any considerable changes in markers of inflammation but showed evidence for lowered serum leptin concentrations relative to the HD group.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30306 - Sport and fitness sciences
Result continuities
Project
<a href="/en/project/GA18-08358S" target="_blank" >GA18-08358S: The effects of lowering dietary carbohydrates on health, exercise performance and wellbeing-related outcomes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrition and Health
ISSN
0260-1060
e-ISSN
2047-945X
Volume of the periodical
26
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
35-42
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85078913920