Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17450%2F20%3AA21026AQ" target="_blank" >RIV/61988987:17450/20:A21026AQ - isvavai.cz</a>

Result on the web

<a href="https://journals.lww.com/menopausejournal/Abstract/2020/10000/Peripheral_vasodilation_is_reduced_during_exercise.11.aspx" target="_blank" >https://journals.lww.com/menopausejournal/Abstract/2020/10000/Peripheral_vasodilation_is_reduced_during_exercise.11.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/GME.0000000000001582" target="_blank" >10.1097/GME.0000000000001582</a>

Result language

angličtina

Original language name

Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk

Original language description

Objective: The menopausal transition has a negative effect on peripheral dilation in response to various stimuli including shear stress and exercise. Whether the presence of elevated traditional cardiovascular disease (CVD) risk factors in women going through menopause exacerbates the adverse effect on peripheral vasodilation is unclear. Methods: Forty-four perimenopausal women with relatively low CVD risk were divided into tertiles based on atherosclerotic CVD (ASCVD) 10-year risk scores (lowest: 0.1%-0.5%, middle: 0.6%-0.9%, higher: >1%). Comparisons were made across tertile groups for the femoral artery vascular conductance (FVC) response to single-leg knee extension exercise (0, 5, 10, 15 W) as measured using Doppler ultrasound. Results: At higher exercise intensities, FVC was lower in women in the tertile group with the highest ASCVD 10-year risk scores (10 W: 6 ± 2 mL/min/mm Hg, 15 W: 8 ± 3 mL/min/mm Hg) compared to women in the lowest tertile group (10 W: 9 ± 3 mL/min/mm Hg, P = 0.01; 15 W: 12 ± 3 mL/min/mm Hg, P < 0.01) and middle tertile group (10 W: 10 ± 4 mL/min/mm Hg, P < 0.01; 15 W: 12 ± 5 mL/min/mm Hg, P < 0.01). The overall increase in FVC during exercise from 0 to 15 W remained lower (P ≤ 0.01) in women with the highest ASCVD risk scores compared to the other two tertile groups even after adjustment for chronological age, arterial stiffness, and fat-free mass adjusted aerobic fitness level. Conclusion: Our results show that the presence of mild differences in ASCVD risk scores may be associated with a blunted active limb blood flow during leg exercise in mid-life women transitioning through menopause.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30306 - Sport and fitness sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Menopause

ISSN

1072-3714

e-ISSN

1530-0374

Volume of the periodical

27

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

1167-1170

UT code for WoS article

000588147200011

EID of the result in the Scopus database

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