Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F18%3A10239148" target="_blank" >RIV/61989100:27350/18:10239148 - isvavai.cz</a>

Result on the web

<a href="http://www.expresspolymlett.com/index.html?tartalom=content.php&year=2018&number=1&kodnumber=1" target="_blank" >http://www.expresspolymlett.com/index.html?tartalom=content.php&year=2018&number=1&kodnumber=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3144/expresspolymlett.2018.8" target="_blank" >10.3144/expresspolymlett.2018.8</a>

Result language

angličtina

Original language name

Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing

Original language description

Application of human mesenchymal stem cells brings a new hope for advanced wound healing. To enable cells culture and their viability maintenance, a new type of biomaterials must be developed. Scaffolds prepared from polymers of natural origin can mimic extracellular matrix. Chitosan, which is a chitin derivative, has many favorable properties like biodegradability or lack of cytotoxicity. Therefore, it is widely applied in medicine and pharmacy. Nevertheless, its chemical modification may lead to the loss of biocompatibility of the material and generate some significant problems with cells culture. In this article a novel strategy of the bioactive and antimicrobial chitosan hydrogel scaffolds is presented. As crosslinking agents non-toxic substances were used such as aspartic acid and glutamic acid. Obtained biomaterials were investigated over their chemical structure, morphology and biological activity. Performed tests using human mesenchymal stem cells confirmed bioactivity and biocompatibility, as well as antibacterial and antifungal properties.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20601 - Medical engineering

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Express Polymer Letters

ISSN

1788-618X

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

HU - HUNGARY

Number of pages

13

Pages from-to

100-112

UT code for WoS article

000417024000008

EID of the result in the Scopus database

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