Influence of Temperature and pH on the Properties of Polymeric Drug Carriers: A Molecular Modeling Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F16%3A86099862" target="_blank" >RIV/61989100:27640/16:86099862 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27740/16:86099862
Result on the web
<a href="http://dx.doi.org/10.1166/asl.2016.6913" target="_blank" >http://dx.doi.org/10.1166/asl.2016.6913</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/asl.2016.6913" target="_blank" >10.1166/asl.2016.6913</a>
Alternative languages
Result language
angličtina
Original language name
Influence of Temperature and pH on the Properties of Polymeric Drug Carriers: A Molecular Modeling Study
Original language description
Classical molecular dynamics was used for the characterization of two biodegradable polymers (chitosan and polyethylene glycol) serving as a carriers of a non-steroidal anti-inflammatory drug Ibuprofen. An attention was paid to the behavior of polymer/ibuprofen systems in aqueous solutions under various conditions. Temperatures simulating normal (309 K) and elevated (313 K) temperature of human body and pH values corresponding to biological (pH = 7) and gastric fluids (pH = 1) were used in the models. Polymer/ibuprofen systems were characterized by four parameters: non-bond interaction energy, volume fraction, amount of pervaded water and mutual distances between drug molecules and polymeric chains. Molecular modeling revealed different behavior of chitosan and polyethylene glycol carriers of ibuprofen in aqueous solution in dependence on temperature and pH.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: IT4Innovations Centre of Excellence</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Advanced Science Letters : 4th Biennial Nanomaterials and Nanotechnology International Conference : proceedings : May 18-21, 2015, Ostrava, Czech Republic
ISBN
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ISSN
1936-6612
e-ISSN
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Number of pages
6
Pages from-to
625-630
Publisher name
American Scientific Publishers
Place of publication
Valencia
Event location
Ostrava
Event date
May 18, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000381233100006