Electrospinning of fibrous layers containing antibacterial chlorhexidine/kaolinite composite
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F20%3A10244806" target="_blank" >RIV/61989100:27640/20:10244806 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27710/20:10244806 RIV/61989100:27740/20:10244806
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsabm.0c00088" target="_blank" >https://pubs.acs.org/doi/10.1021/acsabm.0c00088</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsabm.0c00088" target="_blank" >10.1021/acsabm.0c00088</a>
Alternative languages
Result language
angličtina
Original language name
Electrospinning of fibrous layers containing antibacterial chlorhexidine/kaolinite composite
Original language description
The aim of this study was to prepare self-supporting homogeneous nano/microfibrous layers with a content of the clay mineral kaolinite and kaolinite modified with the antibacterial agent chlorhexidine (CH). Fibers were made of hydrophobic polymers-polyurethane and polycaprolactone. Polymer suspensions for electrospinning contained 2, 5, and 8 wt % (relative to the total weight of the suspension) of kaolinite or CH/kaolinite and were electrospun using 4SPIN LAB. The morphology of prepared fibrous layers was characterized using scanning electron microscopy; energy-dispersive X-ray spectroscopy mapping and Raman spectroscopy were used to confirm the presence and distribution of kaolinite in the layers. Fiber diameters decreased after adding kaolinite or CH/kaolinite and ranged from 600 nm to 5 μm. Antibacterial CH was found in kaolinite itself as well as separately in the fibers (result of imperfect bonding of CH onto the surface of kaolinite). The encapsulation efficiency of all samples exceeded 64%, and the highest efficiency was observed in samples with 2 wt % CH/kaolinite. Samples containing CH exhibited good antibacterial activity against Staphylococcus aureus, and the effectiveness of which was affected by the concentration of the antibacterial agent. The release of CH was very slow, and there was no initial burst release. Overall, no more than 5% of the CH was released over a course of 168 h. The Korsmeyer-Peppas model revealed that CH is released by a diffusion mechanism.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/EF17_049%2F0008441" target="_blank" >EF17_049/0008441: Innovative therapeutic methods of musculoskeletal system in accident surgery</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Bio Materials
ISSN
2576-6422
e-ISSN
—
Volume of the periodical
3
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
3028-3038
UT code for WoS article
000604588000050
EID of the result in the Scopus database
2-s2.0-85087823215