Antimicrobial nanofibrous mats with controllable drug release produced from hydrophobized hyaluronan

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F21%3A10247544" target="_blank" >RIV/61989100:27640/21:10247544 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0144861721006123?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861721006123?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2021.118225" target="_blank" >10.1016/j.carbpol.2021.118225</a>

Result language

angličtina

Original language name

Antimicrobial nanofibrous mats with controllable drug release produced from hydrophobized hyaluronan

Original language description

Due to their large active surface, high loading efficiency, and tunable dissolution profiles, nanofibrous mats are often cited as promising drug carriers or antimicrobial membranes. Hyaluronic acid has outstanding biocompatibility, but it is hydrophilic. Nanofibrous structures made from hyaluronan dissolve immediately, making them unsuitable for controlled drug release and longer applications. We aimed to prepare a hyaluronan-based antimicrobial nanofibrous material, which would retain its integrity in aqueous environments. Self-supporting nanofibrous mats containing octenidine dihydrochloride or triclosan were produced by electrospinning from hydrophobized hyaluronan modified with a symmetric lauric acid anhydride. The nanofibrous mats required no cross-linking to be stable in PBS for 7 days. The encapsulation efficiency of antiseptics was nearly 100%. Minimal release of octenidine was observed, while up to 30% of triclosan was gradually released in 72 h. The nanofibrous materials exhibited antimicrobial activity, the fibroblast viability was directly dependent on the antiseptic content and its release. (C) 2021 Elsevier Ltd

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21000 - Nano-technology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Polymers

ISSN

0144-8617

e-ISSN

—

Volume of the periodical

267

Issue of the periodical within the volume

september

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

—

UT code for WoS article

000662870900004

EID of the result in the Scopus database

2-s2.0-85107736662