Encapsulation of hydrophobic drugs in hyaluronic acid nanofibers: effect of the solution preparation procedure

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F21%3A10249602" target="_blank" >RIV/61989100:27640/21:10249602 - isvavai.cz</a>
Result on the web
<a href="https://cnt.vsb.cz/export/sites/cnt/.content/galerie-souboru/Nanomaterials-and-Nanotechnology-in-2021.pdf" target="_blank" >https://cnt.vsb.cz/export/sites/cnt/.content/galerie-souboru/Nanomaterials-and-Nanotechnology-in-2021.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Encapsulation of hydrophobic drugs in hyaluronic acid nanofibers: effect of the solution preparation procedure
Original language description
Perspective application of nanofibrous mats composed of hydrophilic polymers are the fastdissolving drug delivery systems for immediate release of a wide spectrum of additives, including poorly soluble drugs. For the effective preparation of drug carriers, it is necessary to load additives with high encapsulation efficiency. In our study, we aimed to prepare hyaluronic acid/polyethylenoxide nanofibers with a hydrophobic antiseptic agent (ANT). We have used several approaches of solution preparation to achieve ideally 100 % encapsulation efficiency of ANT. The approaches included dispersing ANT in polymer solution (dispersion), creating an emulsion with the surfactant Tween 60 in water before dissolving the polymers (emulsion), and dissolving all the components in a single solvent system (blend). The morphology of the nanofibers was characterized by SEM, amount of encapsulated ANT was analyzed by HPLC, and the distribution of ANT was mapped by Raman spectroscopy. The best results were obtained by blend electrospinning. The encapsulation efficiency of ANT was over 95 % and ANT was distributed in the nanofiber mat homogeneously. The yield of the electrospinning process was also 3-fold higher than the yield of dispersion and emulsion electrospinning.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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