Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F25%3A10258848" target="_blank" >RIV/61989100:27640/25:10258848 - isvavai.cz</a>
Result on the web
<a href="https://www.pnas.org/doi/10.1073/pnas.2500552122" target="_blank" >https://www.pnas.org/doi/10.1073/pnas.2500552122</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2500552122" target="_blank" >10.1073/pnas.2500552122</a>
Alternative languages
Result language
angličtina
Original language name
Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways
Original language description
Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanoparticles (NPs), their potential infiltration into human breast milk remains poorly understood. This study provides a comprehensive chemical profile of NPs in human breast milk, analyzing their elemental composition, surface charge, hydrodynamic size, and crystallinity. NPs were detected in 42 out of 53 milk samples, with concentrations reaching up to 1.12 x 1011 particles/mL. These particles comprised nine elements, with O, Si, Fe, Cu, and Al being the most frequently detected across all samples. We establish a mechanistic axis for NP infiltration, involving penetration of the intestine/air-blood barriers, circulation in blood vessels, crossing the blood-milk barrier via transcytosis or immune cell-mediated transfer, and eventual accumulation in milk. Structure-activity relationship analysis reveals that smaller, neutral-charged NPs exhibit stronger infiltration capacity, offering potential for regulating NP behavior at biological barriers through engineering design. This study provides the chemical profiles of NPs in human breast milk and uncovers their infiltration pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings Of The National Academy Of Sciences Of The United States Of America
ISSN
0027-8424
e-ISSN
1091-6490
Volume of the periodical
122
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"nestrankovano"
UT code for WoS article
001497519300001
EID of the result in the Scopus database
2-s2.0-105005377565