Enhancing early osteogenic differentiation on Ti6Al4V implants via MAO coatings doped with strontium and calcium
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F25%3A10260240" target="_blank" >RIV/61989100:27640/25:10260240 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0927775725033424" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927775725033424</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2025.139438" target="_blank" >10.1016/j.colsurfa.2025.139438</a>
Alternative languages
Result language
angličtina
Original language name
Enhancing early osteogenic differentiation on Ti6Al4V implants via MAO coatings doped with strontium and calcium
Original language description
Titanium alloys such as Ti6Al4V are widely used in orthopaedic implants due to their excellent mechanical and corrosion-resistant properties. However, insufficient early-stage osseointegration remains a critical challenge, often leading to implant loosening and failure. To overcome this issue, bone implant design and surface modification increasingly focus on incorporating bioactive elements. This study explores the enhancement of osseointegration through micro-arc oxidation (MAO) surface modification of Ti6Al4V, incorporating bioactive strontium (Sr) and calcium (Ca) ions. Two surface pretreatments — polishing (P) or shot-blasting (B) — were applied prior to MAO to generate coatings with distinct topographies and compositions: TAV(P), TAV(P)-Sr, TAV (P)-Sr-Ca, TAV(B), TAV(B)-Sr, and TAV(B)-Sr-Ca. Surface characterization of the resulting oxide layers confirmed the incorporation of Sr, Ca, and phosphate ions, with Sr releasing continuously over 60 days. Wear resistance analysis revealed the highest coefficient of friction for the TAV(P)-Sr coatings and the lowest values for TAV(B)- Sr. Surface modification by blasting led to reduced corrosion resistance in the TAV(B), TAV(B)-Sr, and TAV(B)-Sr- Ca samples. Nevertheless, enhanced corrosion resistance was observed in all samples modified with Sr and Sr+Ca. In vitro analyses using human bone marrow-derived mesenchymal stromal cells (hBMSCs) demonstrated excellent biocompatibility of all coatings. Notably, Sr-doped and especially Sr-Ca-doped surfaces significantly enhanced early osteogenic differentiation, as evidenced by increased alkaline phosphatase activity and type I collagen deposition. These findings highlight the synergistic effects of surface topography and Sr-Ca ion doping in promoting early-stage osseointegration, offering a promising strategy for improving the performance of titanium-based bone implants, particularly in patients with compromised bone healing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20500 - Materials engineering
Result continuities
Project
<a href="/en/project/EH22_008%2F0004631" target="_blank" >EH22_008/0004631: Materials and technologies for sustainable development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
1873-4359
Volume of the periodical
734
Issue of the periodical within the volume
April
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
nestránkováno
UT code for WoS article
001660073600001
EID of the result in the Scopus database
2-s2.0-105026444939