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Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001918" target="_blank" >RIV/61989592:15110/05:00001918 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?

  • Original language description

    Apoptosis was originally defined as a mode of cell death with specific morphology. Since the discovery of caspase proteases, it has been evident that caspase activation was indispensable for apoptosis to occur in various mammalian cell types.

  • Czech name

    Může aplikace inhibitorů serinových proteáz TPCK a TLCK poskytnout důkaz pro možné zapojení serinové proteázy Omi/HtrA2 v buněčné smrti indukované imatinib mesylátem u BCR-ABL pozitivních lidských leukemických buněk?

  • Czech description

    Apoptóza byla původně definována jako způsob buněčné smrti se specifickou morfologií. Od objevu kaspázových proteáz je zřejmé, že aktivace kaspáz je nezbytná ke spuštění apoptózy u různých savčích buněk.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA301%2F04%2F1239" target="_blank" >GA301/04/1239: Sensitivity and resistance of Bcr/Abl leukemia cells to STI571 in vitro</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia

  • ISSN

    0887-6924

  • e-ISSN

  • Volume of the periodical

    19

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    3

  • Pages from-to

    1085-1087

  • UT code for WoS article

  • EID of the result in the Scopus database