p53 - Prognostic factor of malignant transformation of barrett's esophagus.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001933" target="_blank" >RIV/61989592:15110/05:00001933 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

p53 - Prognostic factor of malignant transformation of barrett's esophagus.

Original language description

The most signi&#64257;cant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformationis determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indicationof "preventive" extirpation of the esophagus should be supported by other factors, for example by detection of p53mutation or expression.The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Departmentof Surgery, the p53 level and its correlation with histological &#64257;ndings evaluated in these patients.A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlationwas also con&#64257;rmed by detection of early carcinoma in patients with "preventive" extirpation of the esophagusdue to a high-grade dysplasia.Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may behelpf

Czech name

p53 - prognostický faktor maligní transformace u Baretovho jícnu

Czech description

Nejsignifikantnější prekancerozi rakoviny jícnu je Baretův jícen. Riziko maligní transformace zavísí od stupně dysplastických změn sliznice. Studie opisuje na vzorku 20pacientů s Baretovým jícnem korelaci mezi stupněm dysplazie Baretovho jícnu a mutaci nebo změnenou expresí p53.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

149

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

141-144

UT code for WoS article

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EID of the result in the Scopus database

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