Association of tumour necrosis factor-, lymphotoxin- and HLA-DRB1 gene polymorphisms with Löfgren's syndrome in Czech patients with sarcoidosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001971" target="_blank" >RIV/61989592:15110/05:00001971 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of tumour necrosis factor-, lymphotoxin- and HLA-DRB1 gene polymorphisms with Löfgren's syndrome in Czech patients with sarcoidosis

Original language description

Abstract: Sarcoidosis is a granulomatous disorder showing a clear association with MHC (HLA) class I and class II genes. In order to investigate whether polymorphisms of nearby pro inflammatory genes located within the MHC class III region may also contribute to susceptibility to sarcoidosis or to its clinical manifestation, tumour necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha) genes were chosen for analysis in a case-control association study. In order to evaluate the findings on the TNF-alpha and LT-alpha genes in connection with the closely linked MHC class II region, 'classical' HLA-DRB1 locus was also investigated. Polymerase chain reaction-based methodologies were used in order to characterize two single-nucleotide polymorphisms (TNF-308*G/A and LTA+252*A/G) and HLA-DRB1 allele groups in 114 Czech patients with pulmonary sarcoidosis and 425 healthy controls. LTA+252*G and HLADRB1* 13 allele carriers were more frequent in patients, compared to those in controls

Czech name

Souvislost polymorfismů genů pro TNF-alfa, LT-alfa a HLA-DRB1 s Löfgrenovým syndromem u českých pacientů se sarkoidózou

Czech description

Práce se zabývá odhalením souvislosti vybraných polymorfismů genů pro cytokiny TNF-alfa, LT-alfa v kontextu genu HLA-DRB1 s genetickou predispozicí k sarkoidóze a její klinickou manifestací v české populaci. Byla zjištěna souvislost alely LTA+252*G s vnímavostí k sarkoidóze a alel TNF-308*A, LTA+252*G a HLA-DRB1*03 s klinickou manifestací onemocnění pod obrazem Löfgrenova syndromu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tissue Antigens

ISSN

0001-2815

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

3

Country of publishing house

DK - DENMARK

Number of pages

9

Pages from-to

163-171

UT code for WoS article

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EID of the result in the Scopus database

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