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Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00002012" target="_blank" >RIV/61989592:15110/05:00002012 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment

  • Original language description

    Background: Aberrant expression of either growth factors or growth factor-receptors by stromal cells can be an important factor promoting the growth of solid tumours. It may also affect differentiation of malignant cells and support tumour spread. The aim of the present study was to investigate the hypothesis that basic-fibroblast growth factor (bFGF) and platelet-derived growth factor (PDEGF) may be involved in tumour-stromal microenvironment interactions in primary malignant melanomas. Materials and Methods: PDEGF and bFGF expression in malignant cells and surrounding stromal elements was assessed using indirect immunohistochemistry. Results: It was confirmed that PDEGF can be involved in the reciprocal interactions between tumour cells and stroma, including aberrant angiogenesis. Interestingly, bFGF was present both in malignant melanoma lesions and benign nevi accompanied by different intracellular localisation of the protein, suggesting its implication in regulation of nevus cell

  • Czech name

    Molekulární změny v PDEGF a bFGF u maligních melanomů ve vztahu ke stromálnímu mikroprostředí

  • Czech description

    Aberantní exprese růstových faktorů a jejich receptorů stromálními buňkami může být důležitým faktorem podporujícím růst solidních nádorů. Cílem studie bylo ověřit, zda bazický fibroblastový růstový faktor (bFGF) a růstový faktor krevních destiček (PDEGF) jsou zapojeny do vzájemných interakcí mezi nádorovým a stromálním mikroprostředím u primárních maligních melanomů. Výsledky naznačují, že bFGF a PDEGF participují na progresi maligního melanomu.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FO - Dermatology and venereology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1A8245" target="_blank" >1A8245: Alteration of gene expretion and signal transduction in malignant melanoma cells. Relationship to changes of stromal micro-enviroment.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Anticancer Research

  • ISSN

    0250-7005

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    6B

  • Country of publishing house

    GR - GREECE

  • Number of pages

    6

  • Pages from-to

    4299-4304

  • UT code for WoS article

  • EID of the result in the Scopus database