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Prognostic Factors for Survival of Patients with Non-Hondgkin´s Lymphoma (NHL) after Autologous Peripheral Stem Cell Transplantation (APSCT) - Signle Center Experience

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00002731" target="_blank" >RIV/61989592:15110/06:00002731 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prognostic Factors for Survival of Patients with Non-Hondgkin´s Lymphoma (NHL) after Autologous Peripheral Stem Cell Transplantation (APSCT) - Signle Center Experience

  • Original language description

    Several prognostic factors had been previously reported to be associated with overall and progression-free survival of patients with NHL after APSCT. We present a retrospective single center analysis with special attention to the markers that reflect theactivity of disease at the time of transplantation. 122 patients with NHL indicated for APSCT for high-risk features at diagnosis partial response to first line treatment and/or relapse were included in the study. There were 66 women and 56 men at median age 45.5 years (range 19-66). 47 patients were with diagnosis of diffuse-large cell lymphoma, 34 with follicular lymphoma, 15 with mantle cell lymphoma and 26 patients had other lymphoma subtypes. Patients were transplanted in years 1997-2004. In all cases BEAM was used for conditioning. Median follow-up of patients was 27.0 months (range 3.0-93.9). 50 (41.0%) patients relapsed and 35 (28.7%) died. Age, stage of disease, IPI, bone marrow and extra-nodal involvement, presence of B sympt

  • Czech name

    Prognostické faktory pro přežití pacientů s nehodgkinskými lymphomy (NHL) po autologní transplantaci krvetvorných buněk - nezávislá zkušenost centra

  • Czech description

    U 122 nemocných s NHL po autologní transplantaci periferních krvetvorných buněk byla provedena retrospektivní univariační a multivariační analýza prognostických faktorů s ohledem na celkové přežití a přežití bez návratu onemocnění. Coxovou multivariačníregresní analýzou byla potvrzena prognostická hodnota hladiny LDH před transplantací pro přežití bez návratu onemocnění a hladiny LDH a beta-2-mikroglobulinu před transplantací pro celkové přežití nemocných. Byla tak potvrzena vhodnost vyšetření těchto sérových markerů před provedením transplantace u nemocných s NHL. Supported by grant MSM 6198959205.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biology of Blood and Marrow Transplantation

  • ISSN

    1083-8791

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    181

  • Pages from-to

    120

  • UT code for WoS article

  • EID of the result in the Scopus database