Tumour Suppressor PTEN Regulates Cell Cycle and Protein Kinase B/Akt Pathway in Breast Cancer Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00003108" target="_blank" >RIV/61989592:15110/06:00003108 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/06:00083202 RIV/61989592:15310/06:00010655
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Tumour Suppressor PTEN Regulates Cell Cycle and Protein Kinase B/Akt Pathway in Breast Cancer Cells
Original language description
Background: PTEN is a tumour suppressor protein with phosphatase activity frequently altered in several types of human cancers. Materials and Methods: The PTEN effect was studied on the cell cycle (by bromdeoxyuridine incorporation) and on the phosphatidylinositol-3-kinase/protein kinase B/Akt (P13-K/PKB/Akt) pathway regulating proteins.
Czech name
Nádorový supresor PTEN reguluje buněčný cyklus a signální dráhu proteinkinázy B/Akt v buňkách karcinomu prsu
Czech description
Transfekce nádorového supresoru PTEN snižuje aktivitu cyklin E CDK2 komplexu a inhibuje vstup buněk do S-fáze. Transfekce mutované formy PTEN snižuje expresi p27 a p21 a zvyšuje fosforylaci PKB/Akt.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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