The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004002" target="_blank" >RIV/61989592:15110/07:00004002 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract

Original language description

Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and alcohol can directly or indirectly generate DNA damage, which if unrepaired can give rise to mutations, unregulated cell growth and apoptosis induction. To clarify the role of DNA repair and cell cycle control proteins in UADT cancer susceptibility, we studied the risk in relation to 28 SNPs in 18 DNA repair enzymes and 9 SNPs in 7 cell cycle control genes. A case-control study was conducted from 2000 to 2002 in six centers from Romania, Poland, Russia, Slovakia and the Czech Republic. Patients diagnosed with squamous cell carcinoma of the UADT (n=811) and controls with a recent diagnosis of diseases unrelated to tobacco and alcohol (n=1083) were recruited. For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95%

Czech name

Vztah nádorů horního aerodigestivního traktu a variant v genech pro opravu DNA a buněčného cyklu

Czech description

Bylo studováno riziko vzniku nádorů horního aerodigestivního traktu ve vztahu k 28 SNP u 18 enzymů opravujících DNA a 9 SNP u 7 genů kontrolujících buněčný cyklus. Byla zvolena forma studie případů a kontrol zahrnující 811 případů nádorů a 1083 kontrolních osob.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NR9029" target="_blank" >NR9029: Genetic and behavioral risk factors of pancreatic cancer - an epidemiological study.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

665-671

UT code for WoS article

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EID of the result in the Scopus database

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