Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004163" target="_blank" >RIV/61989592:15110/07:00004163 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women

Original language description

OBJECTIVE: Continuous combined hormone replacement therapy (ccHRT) based on estradiol valerate (E2V) and medroxyprogesterone acetate (MPA) is effective for relief of menopausal symptoms three years or more after the menopause. This study was undertaken to examine the efficacy and tolerability of ccHRT in early postmenopausal women (last menstrual period 1.3 years before study entry). STUDY DESIGN: This was a 52-week, randomized, double-blind, multinational study of ccHRT comprising three different dosecombinations of E2V/MPA in 459 early postmenopausal non-hysterectomized women experiencing 30 or more moderate to severe hot flushes a week and/or vasomotor symptoms requiring treatment. MAIN OUTCOMES MEASURES: The primary endpoint was change in frequency and severity of moderate to severe hot flushes at 12 weeks. Secondary outcome measures included number of bleeding days and evaluation of tolerability. RESULTS: The frequency of hot flushes was reduced by >or=70% after one month (P<0.00

Czech name

Účinnost a snášenlivost kontinuální kombinované hormonální substituční terapie u časně postmenopauzálních žen

Czech description

Kontinuální kombinovaná hormonální substituční terapie (HST) s estradiol valerátem a medroxyprogesteron acetátem byla ověřována v 1 rok trvající, randomizované a dvojitě zaslepené mezinárodní klinické studii, do které bylo zahrnuto 459 žen krátce po menopause. Tato HRT byla efektivní pro potlačení klimakterických symptomů a byla dobře tolerována.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Menopause International

ISSN

1754-0453

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

124-131

UT code for WoS article

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EID of the result in the Scopus database

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