Pathological complete response after primary chemotherapy in a mother and daughter with hereditary breast carcinoma: two case reports

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007562" target="_blank" >RIV/61989592:15110/08:00007562 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pathological complete response after primary chemotherapy in a mother and daughter with hereditary breast carcinoma: two case reports

Original language description

The prognosis of patients with BRCA1-related breast carcinomas is inferior to the patients without BRCA1 mutation, but most of these tumors have a so-called triple negative phenotype characterized by increased chemosensitivity. Information regarding thechemosensitivity of BRCA1-related breast carcinomas is limited. We present a case of a mother and daughter with hereditary breast carcinoma treated with primary chemotherapy using the dose-dense combination of doxorubicin and cyslophosphamide and sequential weekly paclitaxel administration. Pathological complete response was observed in both patients. Subsequent genetic analysis revealed the same BRCA1 mutation with exon 5-14 deletion in both women. The present experience as well as other reports indicate increased sensitivity of BRCA1-related breast carcinoma to primary chemotherapy

Czech name

Kompletní patologická odpověď u matky a dcery s karcinomem prsu

Czech description

Popsán případ patologické kompletní odpovědi u matky a dcery s karcinomem prsu a nutná BRCA1.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Gynaecological Oncology

ISSN

0392-2936

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

29

Country of publishing house

CA - CANADA

Number of pages

3

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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