Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A10213704" target="_blank" >RIV/61989592:15110/08:10213704 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.

Original language description

Exposure to UVA radiation is known to cause many adverse biological effects by inducing the stricken cells to produce reactive oxygen species (ROS). In recent years the use of botanicals has received considerable interest in the skin protection. Bilberry(Vaccinium myrtillus L.) fruit contains several polyphenols with strong antioxidant and anti-inflammatory properties. In this study we evaluated potential UVA preventive effect of V. myrtillus fruit extract (VME; anthocyanins, 25 % w/w) in HaCaT keratinocytes. Pre-treatment (1 h) or post-treatment (4 h) of HaCaT with VME resulted in attenuation of UVA-caused damage. Application of the extract significantly reduced UVA-stimulated ROS formation in keratinocytes. VME also prevented/reduced UVA-caused peroxidation of membrane lipids and depletion of intracellular GSH. The observed cytoprotective effect may be linked to the antioxidant activity of the plant constituents, namely anthocyanins.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BioFactors

ISSN

0951-6433

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

4

Country of publishing house

JP - JAPAN

Number of pages

18

Pages from-to

249-266

UT code for WoS article

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EID of the result in the Scopus database

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