Philadelphia chromosome positive (Ph+) leukemia cells are not enriched in the primitive (CD34+CD38-) stem cell fraction during tyrosine kinase inhibitor therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A10224404" target="_blank" >RIV/61989592:15110/08:10224404 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Philadelphia chromosome positive (Ph+) leukemia cells are not enriched in the primitive (CD34+CD38-) stem cell fraction during tyrosine kinase inhibitor therapy

Original language description

Targeted tyrosine kinase inhibotors (TKIs) efficiently induce rapid hematologic and cytogenetic remission in most chronic myeloid leukemia (CML) patients. however, a small population of resistant primitive leukemia stem cells remains even after years ontherapy, as rapid leukamia relapse occurs in patients who discontinue TKI therapy. In vitro experiment have suggested that the most primitive CML stm cells reside in the CD34+CD38- fraction of bone marrow (BM) and are relatively resistant to TKIs, but thus far there are no reports describing the prevalence of these cells in patients under TKI therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica: the hematology journal

ISSN

0390-6078

e-ISSN

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Volume of the periodical

93

Issue of the periodical within the volume

1

Country of publishing house

IT - ITALY

Number of pages

2

Pages from-to

41-42

UT code for WoS article

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EID of the result in the Scopus database

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