Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A33117551" target="_blank" >RIV/61989592:15110/08:33117551 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis
Original language description
Bone remodeling is a tighitly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, with operate in conjuction with local and systemic factors in a discrete anatomic structuredesignated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influence by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this maylead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have reported the past, including RANKL/RANK/TRAF6, TNF-alpha/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expressions and functional activity of all these Molecules can be affected by variations in their genes. These may explai the differences in severity of bone defec
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
—

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)