The Anti - inflammatory effects of Inhaled Corticosteroids versus Anti-Leukotrienes on the Lymphocyte P- Glycoprotein ( PGP) Expresion in Asthmatic Children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009517" target="_blank" >RIV/61989592:15110/09:00009517 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Anti - inflammatory effects of Inhaled Corticosteroids versus Anti-Leukotrienes on the Lymphocyte P- Glycoprotein ( PGP) Expresion in Asthmatic Children

Original language description

BACKGROUND: Inhaled corticosteroids (ICS) are used in asthma therapy for their anti-inflammatory effects. P-glycoprotein (PGP) is a transmembrane efflux pump for many drugs, including corticosteroids. Expression of PGP is associated with therapy resistant disease. OBJECTIVE: The purpose of this study was to compare expression levels of PGP in blood lymphocytes of pediatric asthma patients either on ICS or on the leukotriene inhibitor montelukast medication. PATIENTS AND METHODS: The evaluation of lymphocyte PGP expression was performed on a sample of 99 children (66 boys and 33 girls) aged 2-18 (median 12) years with intermittent or persisting mild asthma, (as defined by GINY 2002). The asthmatic children were divided into 3 groups: (1) treated by ICSbudesonide 200-400 microg per day (n = 27) more than 1 year; (2) treated by oral montelukast 4 or 5 mg at an age-based dose (n = 16); and (3) treated by inhaled corticosteroids and montelukast (n = 45). Reference PGP values were obtained

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR8954" target="_blank" >NR8954: Detection of P-glycoprotein genes polymorphism as product of MDR1 gene (MDR1/Pgp) and MRP and expression of PgP, MRP1 and LRP on lymphocytes in patients with bronchial asthma, Croh´n disease and ulcerative colitis.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Asthma

ISSN

0277-0903

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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