Lipid-Altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolemic patients inadequately controlled with prior statin monotherapy - the IN-CROSS study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009535" target="_blank" >RIV/61989592:15110/09:00009535 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lipid-Altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolemic patients inadequately controlled with prior statin monotherapy - the IN-CROSS study

Original language description

To evaluate the efficacy of switching from a previous statin monotherapy to ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg vs. rosuvastatin (ROSUVA) 10 mg. In this randomised, double-blind study, 618 patients with documented hypercholesterolaemia (low-density lipoprotein cholesterol /LDL-C/ >=2.59 and <=4.92 mmol/l) and with high cardiovascular risk who ware taking a stable daily dose of one of several statin medications for >=6 weeks prior to the study randomisation visit entered a 6-week open-label stabilisation/screening period during which they continued to receive their prestudy statin dose. Following stratification by study site and statin dose/porency, patients were randomise do EZE/SIMVA 10/20 mg (n=314 or ROSUVA 10 mg (n=304) for 6 weeks. Conclusion: EZE/SIMVA 10/20 mg produced greater improvements in LDL-C, total cholesterol, non-HDL-C and apoB with a similar safety profile as for ROSUVA 10 mg.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The international journal of clinical practice

ISSN

1368-5031

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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