Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009655" target="_blank" >RIV/61989592:15110/09:00009655 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

Original language description

The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P= 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

<a href="/en/project/ME%20856" target="_blank" >ME 856: Polymorphism in genes for chemotactic cytokines and their receptors in Slavonic patients with myocardial infarction</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

—

Volume of the periodical

2009

Issue of the periodical within the volume

390951

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—