Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension
Result description
The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P= 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.
Keywords
CRPMCP-1 polymorphismischemic heart diseaseangina pectorishypertensioninflammation
The result's identifiers
Result code in IS VaVaI
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension
Original language description
The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P= 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.
Czech name
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Czech description
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Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mediators of Inflammation
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2009
Issue of the periodical within the volume
390951
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
EC - Immunology
Year of implementation
2009