High mobility group box-1 (HMGB-1) in osteoarthritic cartilage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10215820" target="_blank" >RIV/61989592:15110/10:10215820 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

High mobility group box-1 (HMGB-1) in osteoarthritic cartilage

Original language description

Nucleosomal high mobility group box-1 (HMGB-1) is translocated and released from necrotic and activated cells as an endogenous danger signal (alarmin) and cytokine. It was hypothesised that it plays a role in osteoarthritis (OA) characterised by cellularactivation, inflammation and enchondral bone formation. In resting chondrocytes tight nucleosomal HMGB-1 binding might cause steric hindrance of immunostaining. TNF-alpha or OA-mediated activation leads to nuclear staining and cytoplasmic transplocation. Advancing OA leads to increasingly intense extra-pericellular deposition of HMGB-1 alarmin, indicating local chondrocyte activation and/or necrosis.In particular, HNGB-1 at the tidemark might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Rheumatology

ISSN

0392-856X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

4

Country of publishing house

IT - ITALY

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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