Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10222123" target="_blank" >RIV/61989592:15110/11:10222123 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

Original language description

UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, "non-skin" tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver.Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in pla

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GP303%2F07%2FP314" target="_blank" >GP303/07/P314: Photoprotective effects of natural plant phenolics in vitro and in vivo</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological & Pharmaceutical Bulletin

ISSN

0918-6158

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

4

Country of publishing house

JP - JAPAN

Number of pages

9

Pages from-to

471-479

UT code for WoS article

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EID of the result in the Scopus database

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