Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223892" target="_blank" >RIV/61989592:15110/11:10223892 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0023022" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0023022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0023022" target="_blank" >10.1371/journal.pone.0023022</a>
Alternative languages
Result language
angličtina
Original language name
Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile
Original language description
Before the era of tyrosine kinase inhibitors (TKIs), interferon-alpha (IFN-a) was the treatment of choice in chronic myeloid leukemia (CML). Curiously, some IFN-a treated patients were able to discontinue therapy without disease progression. The aim of this project was to study the immunomodulatory effects of IFN-a in CML patients in prolonged remission and isolate biological markers predicting response. Due to rarity of patients on IFN-a monotherapy, a relatively small cohort of patients still on treatment (IFN-ON, n = 10, median therapy duration 11.8 years) or had discontinued IFN-a therapy but remained in remission for .2 years (IFN-OFF, n = 9) were studied.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"e23022"
UT code for WoS article
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EID of the result in the Scopus database
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