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Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223892" target="_blank" >RIV/61989592:15110/11:10223892 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1371/journal.pone.0023022" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0023022</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pone.0023022" target="_blank" >10.1371/journal.pone.0023022</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile

  • Original language description

    Before the era of tyrosine kinase inhibitors (TKIs), interferon-alpha (IFN-a) was the treatment of choice in chronic myeloid leukemia (CML). Curiously, some IFN-a treated patients were able to discontinue therapy without disease progression. The aim of this project was to study the immunomodulatory effects of IFN-a in CML patients in prolonged remission and isolate biological markers predicting response. Due to rarity of patients on IFN-a monotherapy, a relatively small cohort of patients still on treatment (IFN-ON, n = 10, median therapy duration 11.8 years) or had discontinued IFN-a therapy but remained in remission for .2 years (IFN-OFF, n = 9) were studied.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS One

  • ISSN

    1932-6203

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    "e23022"

  • UT code for WoS article

  • EID of the result in the Scopus database