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In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10225189" target="_blank" >RIV/61989592:15110/11:10225189 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans

  • Original language description

    Lasioglossins represent a new group of amhipathic peptides with remarkable antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LLIII and D-LLIII as meassured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay the inhibitory effect of lasioglossins LLIII and D-LLIII was more than 70% within 24h and more than 84% after 48hof incubation (final concentration of iether peptide was 11,5 ?M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Collection Symposium series

  • ISBN

    978-80-86241-44-9

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    54-57

  • Publisher name

    Institute of Organic Chemistry and Biochemistry

  • Place of publication

    Prague

  • Event location

    Prague, Czech Republic

  • Event date

    Apr 27, 2011

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article