In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10225189" target="_blank" >RIV/61989592:15110/11:10225189 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans
Original language description
Lasioglossins represent a new group of amhipathic peptides with remarkable antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LLIII and D-LLIII as meassured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay the inhibitory effect of lasioglossins LLIII and D-LLIII was more than 70% within 24h and more than 84% after 48hof incubation (final concentration of iether peptide was 11,5 ?M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Collection Symposium series
ISBN
978-80-86241-44-9
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
54-57
Publisher name
Institute of Organic Chemistry and Biochemistry
Place of publication
Prague
Event location
Prague, Czech Republic
Event date
Apr 27, 2011
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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