Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A33118318" target="_blank" >RIV/61989592:15110/11:33118318 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/11:33118318
Result on the web
<a href="http://dx.doi.org/10.1016/j.carres.2011.07.026" target="_blank" >http://dx.doi.org/10.1016/j.carres.2011.07.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2011.07.026" target="_blank" >10.1016/j.carres.2011.07.026</a>

Result language
angličtina
Original language name
Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study
Original language description
A number of 5-alkoxymethyluracil analogues were synthesized in order to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukemia cells and solid tumor derived cell lines. In addition to this, the cytotoxic activity of 5-alkoxymethyluracil analogues 1,2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3,4. Extensive structure-cytotoxic activity relationship studies are reported.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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