Effect of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiogram substudy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A33148888" target="_blank" >RIV/61989592:15110/11:33148888 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/eurheartj/ehr311" target="_blank" >http://dx.doi.org/10.1093/eurheartj/ehr311</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/eurheartj/ehr311" target="_blank" >10.1093/eurheartj/ehr311</a>
Alternative languages
Result language
angličtina
Original language name
Effect of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiogram substudy
Original language description
Aims The SHIFT echocardiographic substudy evaluated the effects of ivabradine on left ventricular (LV) remodelling in heart failure (HF). Methods and results Eligible patients had chronic HF and systolic dysfunction [LV ejection fraction (LVEF) ?35%], were in sinus rhythm, and had resting heart rate ?70 bpm. Patients were randomly allocated to ivabradine or placebo, superimposed on background therapy for HF. Complete echocardiographic data at baseline and 8 months were available for 411 patients (ivabradine 208, placebo 203). Treatment with ivabradine reduced LVESVI (primary substudy endpoint) vs. placebo [?7.0 +- 16.3 vs. ?0.9 +- 17.1 mL/m2; difference (SE), ?5.8 (1.6), 95% CI ?8.8 to ?2.7, P{ 0.001]. The reduction in LVESVI was independent of beta-blocker use, HF aetiology, and baseline LVEF. Ivabradine also improved LV end-diastolic volume index (?7.9 +- 18.9 vs. ?1.8 +- 19.0 mL/m2, P= 0.002) and LVEF (+2.4 +- 7.7 vs. ?0.1 +- 8.0%, P{ 0.001). The incidence of the SHIFT primary compo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Heart Journal (print)
ISSN
0195-668X
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
20
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
2507-2515
UT code for WoS article
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EID of the result in the Scopus database
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