MicroRNAs: emerging regulators of immune-mediated diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A10224750" target="_blank" >RIV/61989592:15110/12:10224750 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1365-3083.2011.02650.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-3083.2011.02650.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1365-3083.2011.02650.x" target="_blank" >10.1111/j.1365-3083.2011.02650.x</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNAs: emerging regulators of immune-mediated diseases
Original language description
MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression in humans: they regulate one third of human protein-coding genes. These small non-coding ?22 nucleotides (nt) long RNAs originate by multistep process from miRNA geneslocalized in the genomic DNA. To date, more than 1420 miRNAs have been identified in humans (miRBase v17). The main mechanism of miRNA action is the posttranscriptional regulation via RNA interference with their target mRNAs. The majority of target mRNAs(more than 80%) undergo degradation after recognition by complementary miRNA; the translational inhibition with little or no influence on mRNA levels has been also reported. Each miRNA may suppress multiple mRNA targets (average ?200) and at the same time one mRNA can be targeted by many miRNAs enables to control a spectrum wide range of cellular processes.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scandinavian Journal of Immunology
ISSN
1365-3083
e-ISSN
—
Volume of the periodical
75
Issue of the periodical within the volume
2
Country of publishing house
NO - NORWAY
Number of pages
13
Pages from-to
129-141
UT code for WoS article
—
EID of the result in the Scopus database
—