High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33117919" target="_blank" >RIV/61989592:15110/12:33117919 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10428194.2011.654339" target="_blank" >http://dx.doi.org/10.3109/10428194.2011.654339</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2011.654339" target="_blank" >10.3109/10428194.2011.654339</a>
Alternative languages
Result language
angličtina
Original language name
High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma
Original language description
Abstract Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation. TK1 was reported as a reliable prognostic factor in solid tumors and chronic lymphocytic leukemia, but has not been tested in large populations of non-Hodgkin lymphoma patients yet. In this study, a prognostic significance of TK1 levels was assessed in 170 prospectively enrolled patients with previously untreated follicular lymphoma. The TK1 level at the time of treatment initiation was shown to correlate with theclinical stage, FLIPI score, beta-2 microglobulin level, lactate-dehydrogenase level and B symptoms. No correlation was found with the FL grade or Ki-67 proliferative index. The Cox regression analysis identified high TK1 levels (?15 IU/L) as a prognostic factor for overall survival (hazard ratio 2.91, p=0.019) and progression-free survival (hazard ratio 1.94, p=0.022) independent of FLIPI score variables. Thus, TK1 levels may help refine risk assessment in the modern immunotherapy era.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia & Lymphoma
ISSN
1042-8194
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
1306-1310
UT code for WoS article
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EID of the result in the Scopus database
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