Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138725" target="_blank" >RIV/61989592:15110/12:33138725 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x" target="_blank" >10.1111/j.1399-0039.2012.01886.x</a>
Alternative languages
Result language
angličtina
Original language name
Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
Original language description
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies indicated the increased blood levels of proinflammatory interleukin-6 cytokine in schizophrenia. However, only limited studies explored the relationship between excess production and genetic variations of this cytokine in schizophrenia, and the results were controversial. Here, we investigated possible association of the interleukin-6 gene (IL6) rs1800795 (-174G/C) polymorphism with schizophrenia and relationshipbetween this polymorphism and interleukin-6 protein (IL-6) blood levels. This polymorphism was found by other researchers to associate with different transcription rates and different plasma levels of IL-6. A total of 208 unrelated Armenians were genotyped by polymerase chain reaction with sequence-specific primers, and IL-6 levels were assessed by enzyme-linked immunosorbent assay. The IL6 rs1800795 alleles and genotypes in both groups were in Hardy-Weinberg (H-W) equilibrium. We found
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tissue Antigens
ISSN
0001-2815
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
136-142
UT code for WoS article
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EID of the result in the Scopus database
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