Drug-induced cholestatic liver injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33139127" target="_blank" >RIV/61989592:15110/12:33139127 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Drug-induced cholestatic liver injury
Original language description
The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half ofall reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the
Czech name
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Czech description
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Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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