A novel sarcoidosis risk locus for europeans on chromosome 11q13.1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140029" target="_blank" >RIV/61989592:15110/12:33140029 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >http://dx.doi.org/10.1164/rccm.201204-0708OC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >10.1164/rccm.201204-0708OC</a>
Alternative languages
Result language
angličtina
Original language name
A novel sarcoidosis risk locus for europeans on chromosome 11q13.1
Original language description
Rationale: Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. Objectives: To identify additionalrisk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genome-wide association scan for these phenotypes. Methods: After quality control, the genome-wide association scan comprised nearly 1.3 million imputed single-nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and 1,575 control subjects. Measurements and Main Results: We identified chromosome 11q13.1 (rs479777) as anovel locus influencing susceptibility to sarcoidosis with genome-wide significance. The marker was significantly associated in three distinct German case-control populations and in an additional German family sample with odds ratios rang
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Respiratory and Critical Care Medicine
ISSN
1073-449X
e-ISSN
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Volume of the periodical
186
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
877-885
UT code for WoS article
000311128300014
EID of the result in the Scopus database
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