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A novel sarcoidosis risk locus for europeans on chromosome 11q13.1

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140029" target="_blank" >RIV/61989592:15110/12:33140029 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >http://dx.doi.org/10.1164/rccm.201204-0708OC</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >10.1164/rccm.201204-0708OC</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A novel sarcoidosis risk locus for europeans on chromosome 11q13.1

  • Original language description

    Rationale: Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. Objectives: To identify additionalrisk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genome-wide association scan for these phenotypes. Methods: After quality control, the genome-wide association scan comprised nearly 1.3 million imputed single-nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and 1,575 control subjects. Measurements and Main Results: We identified chromosome 11q13.1 (rs479777) as anovel locus influencing susceptibility to sarcoidosis with genome-wide significance. The marker was significantly associated in three distinct German case-control populations and in an additional German family sample with odds ratios rang

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    American Journal of Respiratory and Critical Care Medicine

  • ISSN

    1073-449X

  • e-ISSN

  • Volume of the periodical

    186

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    877-885

  • UT code for WoS article

    000311128300014

  • EID of the result in the Scopus database