Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140231" target="_blank" >RIV/61989592:15110/12:33140231 - isvavai.cz</a>

Result on the web

<a href="http://www.haematologica.com/content/97/10/1480.full" target="_blank" >http://www.haematologica.com/content/97/10/1480.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2011.059550" target="_blank" >10.3324/haematol.2011.059550</a>

Result language

angličtina

Original language name

Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts

Original language description

Hypochromic microcytic anemia associated with ineffective erythropoiesis caused by recessive mutations in divalent metal transporter 1 (DMT1) can be improved with high-dose erythropoietin supplementation. The aim of this study was to characterize and compare erythropoiesis in samples from a DMT1-mutant patient before and after treatment with erythropoietin, as well as in a mouse model with a DMT1 mutation, the mk/mk mice. We showed that erythropoietin inhibits apoptosis of DMT1-mutant erythroid progenitors and differentiating erythroblasts by increasing STAT5 signaling.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GPP305%2F10%2FP210" target="_blank" >GPP305/10/P210: Consequences of DMT1 deficiency on erythropoiesis.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica: the hematology journal

ISSN

0390-6078

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

10

Country of publishing house

IT - ITALY

Number of pages

9

Pages from-to

1480-1488

UT code for WoS article

000310208400009

EID of the result in the Scopus database

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