Prognostic value of hepatocyte growth factor, syndecan-1, and osteopontin in multiple myeloma and monoclonal gammopathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140629" target="_blank" >RIV/61989592:15110/12:33140629 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/12:#0000262
Result on the web
<a href="http://www.hindawi.com/journals/tswj/2012/356128/" target="_blank" >http://www.hindawi.com/journals/tswj/2012/356128/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1100/2012/356128" target="_blank" >10.1100/2012/356128</a>

Result language
angličtina
Original language name
Prognostic value of hepatocyte growth factor, syndecan-1, and osteopontin in multiple myeloma and monoclonal gammopathy
Original language description
Our aim was to compare serum levels of selected biological parameters in different phases of multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS) to determine their diagnostic and prognostic potential. A cohort of 234 individuals was assessed for serum levels of hepatocyte growth factor (HGF) , syndecan-1/CD138 (SYN), and osteopontin (OPN). The patients with MM (N=156) were divided into 3 groups; at the time of diagnosis (N=45), in relapse/rogression (N=56), and in remission (N=50). The analysis revealed significant differences of all three parameters in comparison of active and remission phase MM. Moreover, the parameters in active myeloma were significantly higher than in MGUS. Within the comparison of active disease (newlydiagnosed and relapsing), there was no significant difference. Similar results were in remission phase MM and MGUS. There was no relationship of pretreatment levels of the parameters to therapeutic response. We conclude that serum levels
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT12451" target="_blank" >NT12451: The significance of the analysis of the pairs of immunoglobulin heavy/light chains by Hevylite TM in monoclonal gammopathy of undetermined significance and multiple myeloma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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